Package: SQUIRE
Type: Package
Title: Statistical Quality-Assured Integrated Response Estimation
Version: 1.0.1
Date: 2025-11-22
Authors@R: 
    person("Richard A.", "Feiss", 
           email = "feiss026@umn.edu", 
           role = c("aut", "cre"),
           comment = c(ORCID = "0009-0008-0409-6042"))
Author: Richard A. Feiss [aut, cre] (ORCID:
    <https://orcid.org/0009-0008-0409-6042>)
Maintainer: Richard A. Feiss <feiss026@umn.edu>
Description: Provides systematic geometry-adaptive parameter optimization with 
    statistical validation for experimental biological data. Combines ANOVA-based 
    validation with systematic constraint configuration testing (log-scale, 
    positive domain, Euclidean) through T,P,E testing. Only proceeds with 
    parameter optimization when statistically significant biological effects 
    are detected, preventing over-fitting to noise. Uses 'GALAHAD' trust region methods with constraint projection from Conn et al. (2000) 
    <doi:10.1137/S1052623497325107>, ANOVA-based validation following Fisher 
    (1925) <doi:10.1007/978-1-4612-4380-9_6>, and effect size calculations 
    per Cohen (1988, ISBN:0805802835). Designed for structured experimental 
    data including kinetic curves, dose-response studies, and treatment 
    comparisons where appropriate parameter constraints and statistical 
    justification are important for meaningful biological interpretation. 
    Developed at the Minnesota Center for Prion Research and Outreach at 
    the University of Minnesota.
License: MIT + file LICENSE
Encoding: UTF-8
Depends: R (>= 4.2.0)
Imports: stats, GALAHAD (>= 1.0.0), knitr
Suggests: testthat (>= 3.0.0), rmarkdown
VignetteBuilder: knitr
RoxygenNote: 7.3.3
Config/testthat/edition: 3
NeedsCompilation: no
URL: https://github.com/RFeissIV/SQUIRE
BugReports: https://github.com/RFeissIV/SQUIRE/issues
Packaged: 2025-11-23 00:38:32 UTC; feiss026
Repository: CRAN
Date/Publication: 2025-11-30 23:40:06 UTC
Built: R 4.4.3; ; 2025-12-01 17:22:22 UTC; windows
