This R package provides a parallel estimation of the mutual information based on entropy estimates from k-nearest neighbors distances and algorithms for the reconstruction of gene regulatory networks.
Find more details in the paper:
Gabriele Sales, Chiara Romualdi, parmigene—a parallel R package for mutual information estimation and gene network reconstruction, Bioinformatics, Volume 27, Issue 13, 1 July 2011, Pages 1876–1877, https://doi.org/10.1093/bioinformatics/btr274